Central nervous system leukaemia.

Development of CNS leukaemia in acute myeloid leukaemia in childhood.

In 130 cases of acute myeloid leukaemia in children below the age of 14 years in Great Britain, there were 21 cases in which the central nervous system was involved. The incidence and timing is similar to that of acute lymphoblastic leukaemia; in a small number of patients who received prophylactic treatment, involvement of the central nervous system was prevented.

Diagnosis of central nervous system leukaemia.

Survival of twenty-two months in a patient with primary plasma cell leukaemia treated with melphalan and prednisolone.

In the majority of cases plasma cell leukaemia is a rapidly fatal disease with a mean survival time of five months. There have been reports of increased survival using various regimens of chemotherapy although most cases eventually relapse. We describe a patient with primary plasma cell leukaemia who responded to a combination of oral melphalan and prednisolone with control of the disease in th...

Leukoencephalopathy after prophylactic radiation for leukaemia in ataxia telangiectasia.

Children with ataxia telangiectasia have a high probability of developing acute lymphoblastic leukaemia, and have increased sensitivity to chemotherapy and irradiation. We report a 51/2 year old boy who had undiagnosed ataxia telangiectasia when he presented with acute lymphoblastic leukaemia. He subsequently developed a chemoradiation induced leukoencephalopathy after conventional central nerv...

Childhood leukaemia presenting in the central nervous system JOHN GRAHAM POLE

Graham Pole, J. (1973). Archives of Disease in Childhood, 48, 867. Childhood leukaemia presenting in the central nervous system. Four children are described with acute leukaemia of the stem cell variety that presented with cerebral manifestations. The clinical course was practically unaffected by cytotoxic therapy. The cytology of other cases with cerebral involvement at the time of initial dia...

Childhood leukaemia presenting in the central nervous system.

Graham Pole, J. (1973). Archives of Disease in Childhood, 48, 867. Childhood leukaemia presenting in the central nervous system. Four children are described with acute leukaemia of the stem cell variety that presented with cerebral manifestations. The clinical course was practically unaffected by cytotoxic therapy. The cytology of other cases with cerebral involvement at the time of initial dia...